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罗敏敏

发布日期：2018-11-08
            

研究员   清华-IDG/麦戈文脑科学研究院
教授       清华大学生命科学学院
研究员    清华北京生命科学研究所

            
电子邮件: luominmin@nibs.ac.cn
                     
        

[研究兴趣]                          

奖赏与惩罚驱使动物接近或逃避、产生快乐与痛苦、并指导学习与记忆形成。奖赏与惩罚关乎动物的生死与种系繁衍、并在人类的日常生活中影响情绪与情感。小鼠与人有类似的神经环路，并对奖赏与惩罚有相似的行为反应。我们实验室以转基因小鼠为模型，研究哺乳动物处理奖赏与惩罚的神经环路机制，特别是中缝背核及内侧缰核两个脑区及相连的神经环路的作用。我们运用电生理和光学成像，从清醒小鼠中记录特定类型神经元的在奖赏与惩罚相关行为中的反应特点。继而运用光遗传学及化学遗传学手段，检测激活、抑制、损毁相关神经元对于行为的影响。我们也利用全细胞膜片钳和光学成像等手段，探索不同药物及细胞信号转导途径在奖赏与惩罚行为中的作用及分子细胞机制。脑内处理奖赏与惩罚的神经环路异常导致多种人类精神疾病，包括抑郁、精神分裂、药物成瘾等。因此，我们的工作不仅有助于理解与奖赏与惩罚相关行为的神经生物学基础，亦可具有临床意义。

[简历]                             

2012-至今      清华-IDG/麦戈文脑科学研究院，研究员
2009-至今      清华大学生命科学学院，教授
2005-至今      北京生命科学研究所, 研究员
2004-2005     中科院神经科学研究所，研究员
2000-2004     美国杜克大学神经生物学系，博士后
2000              美国宾夕法尼亚大学神经学，博士
1997              美国宾夕法尼亚大学计算机科学，硕士
1995              北京大学心理学，学士

[部分发表]                             

  • Lin R, Feng Q, Li P, Zhou P, Wang R, Liu Z, Wang Z, Qi Z, Tang N, Shao F, Luo M* (2018) A hybridizationchain-reaction-based method for amplifying immunosignals. Nature Methods doi:10.1038/nmeth.4611.
  • Li Y, Zeng J, Zhang J, Yue C, Zhong W, Liu Z, Feng Q, Luo M* (2018) Hypothalamic Circuits for Predation and Evasion Neuron 97, 911–924, doi:10.1016/j.neuron.2018.01.005.
  • Zhong W, Li Y, Feng Q, Luo M* (2017) Learning and Stress Shape the Reward Response Patterns of Serotonin Neurons. J Neurosci 37, 8863-8875.
  • Wang D, Li Y, Feng Q, Guo Q, Zhou J, Luo M* (2017) Learning shapes the aversion and reward responses of lateral habenula neurons. eLife 6:e23045.
  • Luo J., Feng Q, Wei LCA, Luo M* (2017) Optogenetic activation of dorsal raphe neurons rescues the autistic-like social deficits in?Shank3? knockout mice. Cell Res DOI: 10.1038/cr.2017.52.
  • Zhang J, Tan L, Ren Y, Liang J, Lin R, Feng Q, Zhou J, Hu F, Ren J, Wei C, Yu T, Zhuang Y, Bettler B, Wang F, Luo M* (2016) Presynaptic excitation via GABAB?receptors in habenula cholinergic neurons regulates fear memory expression. Cell 166:716–728. DOI:?10.1016/j.cell.2016.06.026.
  • Li Y, Zhong W, Wang D, Feng Q, Liu Z, Zhou J, Jia C, Hu F, Zeng J, Guo Q, Fu L, Luo M*(2016) Serotonin neurons in the dorsal raphe nucleus encode reward signals. Nature Comms 7:10503 doi: 10.1038/ncomms10503.
  • Guo Q, Zhou J, Feng Q, Lin R, Gong H, Luo Q, Zeng S, Luo M*, Fu L* (2015) Multi-channel fiber photometry for population neuronal activity recording. Biomedical Optics Express 6:3919-3931. doi: 10.1364/BOE.6.003919.
  • Wang D, He X, Zhao Z, Feng Q, Lin R, Sun Y, Ding T, Xu FCA, Luo M*, Zhan C*? (2015) Whole-brain mapping of the direct inputs and axonal projections of pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons. Front. Neuroanat. DOI 10.3389/fnana.2015.00040.
  • Liu Z, Zhou J,? Li Y, Hu F, Wang D, Lu Y, Ma M, Feng Q, Zhang J, Zeng J, Bao, Kim J, Chen Z, Mestikawy SE, Luo M* (2014) Dorsal raphe neurons signal reward through 5-HT and glutamate. Neuron 81:1360–1374.
  • Zhan CCA, Zhou J, Feng Q, Zhang J, Lin S, Bao J, Wu P, Luo M*(2013) Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively. J Neurosci 33:3624–3632.
  • Qin C, Luo M* (2009) Neurochemical Phenotypes of the Afferent and Efferent Projections of the Mouse Medial Habenula. Neuroscience, doi/10.1016/j.neuroscience.2009.03.085
  • Fan S, Luo M* (2009) The Organization of Feedback Projections in a Pathway Important for Processing Pheromonal Signals Neuroscience, doi/10.1016/j.neuroscience.2009.03.065
  • Sun L, Wan H, Hu J, Han J, Matsunami H, Luo M* (2009) Guanylyl Cyclase-D in the Olfactory CO2 Neurons is Activated by Bicarbonate. PNAS, 106:2041-2046.
  • Yan Z, Tan J, Qin C, Lu Y, Ding C, Luo M* (2008) Precise Circuitry Links Bilaterally Symmetric Olfactory Maps. Neuron 58:613–624. (Featured in a preview by Takeshi Imai and Hitoshi Sakano within the same issue of Neuron 58:456-467).
  • Bian X, Yanagawa Y, Chen WR, Luo M* (2008) Cortical-like Functional Organization of the Pheromone-processing Circuits in the Medial Amygdala. J Neurophysiol, 99:77-86.
  • Luo M* (2008) The Necklace Olfactory System in Mammals. J Neurogenetics, 22:229-238.
  • Hu J, Zhong C, Ding C, Chi Q, Walz A, Mombaerts P, Matsunami H, Luo M* (2007) Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem. Science, 317:953-957.
  • Luo, M* and Katz LC (2004) Encoding Pheromones by the Mammalian Vomeronasal System. Curr Opinion Neurobiol 14:428-34.
  • Luo, M*. (2004) Got milk? A pheromonal message for newborn rabbits. Bioessays 26:6-9.
  • Luo, M*, Fee, MS, and Katz, LC (2003) Encoding pheromonal signals in the accessory olfactory bulb of behaving mice. Science 299:1196-1201.
  • Luo, M* and Katz, LC (2001) Response correlation maps of neurons in the mammalian olfactory bulb. Neuron 32:1165-1179.
  • Luo, M*, Ding, L, and Perkel, DJ (2001) An avian basal ganglia pathway essential forvocal learning nucleus in the zebra finch song system forms closed topographic loops. J Neurosci 21:6836-45.
  • Luo, M*, and Perkel, DJ (1999) A GABAergic, strongly inhibitory projection to a thalamic nucleus in the zebra finch song system. J Neurosci. 19(15):6700-11.
  • Luo, M*, and Perkel, DJ (1999) Long-range GABAergic projection in a circuit essential for vocal learning. J Comp Neurol 403: 68-84.