2023年11月21日神经前沿研讨会

发布日期:2023-11-17

 

   

时间

2023年11月21日,12:00-13:00

地点

生物医学馆E203

报告人

佘心宇(直博五年级)

题目

Investigating the Pathogenic Mechanism of Type I Bipolar Disorder in iPSC-derived Brain Organoid Model

摘要

Type-I bipolar disorder (BDI) is a chronic, complex psychiatric disorder with an incidence of ~0.6-1.0%, however, the molecular mechanisms underlying BDI have remained largely elusive. Lithium (Li) is an effective and well-established mood stabilizer for BDI patients, although approximately 30-40% of patients fail to show positive response to Li. Due to the difficulties in directly analyzing the human brain, brain organoids derived from induced pluripotent stem cells (iPSCs) have emerged as a powerful tool for investigating the pathogenic mechanisms of BDI. To explore the midbrain pathogenic mechanisms of BDI and mechanisms of lithium response, we differentiated iPSC-derived midbrain organoids from 4 healthy controls and 6 BDI patients (3 Li responders, LR, and 3 Li non-responders, NR). We observed the widespread transcriptional dysregulation and aberrant cell composition in BDI midbrain organoids. Moreover, the expression of AQP4 was attenuated in BDI midbrain organoids, which may play a role in the mechanism of lithium response. Our findings provide molecular insights into the pathogenesis of BDI and mechanisms of lithium response.

 

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