Bai Lu's group and Wei Guo's group published 'Therapeutic potential of a TrkB agonistic antibody for Alzheimer's disease' in Theranostics

Date:2020-05-23

On May.23, 2020, Bai Lu's group and Wei Guo's group published 'Therapeutic potential of a TrkB agonistic antibody for Alzheimer's disease' in Theranostics.

Abstract

Repeated failures of “Aβ-lowering” therapies call for new targets and therapeutic approaches for Alzheimer's disease (AD). We propose to treat AD by halting neuronal death and repairing synapses using a BDNF-based therapy. To overcome the poor druggability of BDNF, we have developed an agonistic antibody AS86 to mimic the function of BDNF, and evaluate its therapeutic potential for AD.

Paperlink: https://www.thno.org/v10p6854.htm