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Associate Professor,School of Basic Medical Sciences, Tsinghua University
PI, IDG/McGovern Institute, Tsinghua University；Tsinghua-Peking Center for Life Science
Office Phone: +86-10-62792669
Email: zengcai.guo@biomed.tsinghua.edu.cn Office: B104, Biomedicine Hall, Tsinghua University, Beijing,10084
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[Research Focus]
The neural mechanisms of learning and memory. The mammalian brain comprises hundreds of distinct regions, interconnected by intricate neural fibers to form a dynamic network capable of flexibly processing information in real-time based on varying circumstances. External sensory information is temporarily stored as working memory upon entering the brain, guiding subsequent actions. Working memory serves as the foundation for cognitive functions such as learning, reasoning, decision-making, and consciousness. Our lab employs mice as the primary model system, integrating optogenetic manipulation, multi-channel electrophysiology, two-photon imaging, and quantitative behavioral studies to investigate how multi-regional neural networks facilitate the generation and maintenance of working memory, how coordinated changes in multi-regional neural dynamics support the learning of working memory behaviors, and to develop novel structural and functional imaging methods to advance the study of multi-regional neural dynamics. Through the study of brain network functions and the application of new technologies, we aim to ultimately understand the operational mechanisms of working memory networks, provide new insights for the treatment of working memory disorders, and inspire novel network models in artificial intelligence.
[Education & Experience]
2015-present Associate professor, School of Basic Medical Sciences, Tsinghua University
2015-2024 Associate professor, School of Medicine, Tsinghua University
2015-2020 Assistant professor, School of Medicine, Tsinghua University
2015-present PI, IDG/McGovern Institute for Brain Research, Tsinghua University
2015-present PI, Tsinghua-Peking Center for Life Science, Tsinghua University
2010-2015 Postdoctoral Associate, HHMI's Janelia Research Campus
2004-2010 PhD, Applied Mathematics, Harvard University
2002-2004 MS, Solid Mechanics, Tsinghua University
1998-2002 BS, Engineering Mechanics, Tsinghua University
[Selected Publications]
- Zhou S, Zhu Q, Eom M, Fang S, Subach OM, Ran C, ... Guo ZV*, Subach FV* and Piatkevic KD*. A sensitive soma-localized red fluorescent calcium indicator for in vivo imaging of neuronal populations at single-cell resolution. PLoS biology, 2025, 23(4): e3003048.
- Zhang Y, Wang M, Zhu Q, Guo Y, Liu B, Li J, Yao X, Kong C, Zhang Y, Huang Y, Qi H, Wu J*, Guo ZV* & Dai H*. Long-term mesoscale observation of native 3D intercellular dynamics across a mammalian organ by RUSH3D. Cell, 2024.
- Ocklenburg S* and Guo ZV*. Cross-hemispheric communication: Insights on lateralized brain functions. Neuron, 2024, 10.1016/j.neuron.2024.02.010
- Jaramillo J*, and Guo ZV*. Thalamocortical Contributions to Neural Dynamics and Behavior. Book Chap of the Cerebral Cortex and thalamus, Edited by Martin Usrey and S. Murray Sherman
- Geng J, Tang Y, Yu Z, Gao Y, Li W, Lu Y, Wang B, Zhou H, Li P, Liu N, Wang P, Fan Y, Yang Y*, Guo ZV* and Liu X*. Chronic Ca2+ imaging of cortical neurons with long-term expression of GCaMP-X. eLife, https://doi.org/10.7554/eLife.76691
- Yin X, Wang W, Li J, and Guo ZV*. Lateralization of short-term memory in the frontal cortex. Cell Reports, 2022. 40, 111190.
- Lu J, Zhang Z, Yin X, Tang Y, Ji R, Chen H, Guang Y, Gong X, He Y, Zhou W, Wang H, Cheng K, Wang Y, Chen X, Xie P*, and Guo ZV*. An entorhinal-visual cortical circuit regulates depression-like behaviors. Molecular Psychiatry, 2022. 27, 3807–3820.
- Tang Y, Yang H, Chen X, Zhang Z, Yao X, Yin X and Guo ZV*. Opposing regulation of short-term memory by basal ganglia direct and indirect pathways that are coactive during behavior. BioRxiv, 2021: 2021.12. 15.472735.
- Wang Y, Yin X, Zhang Z, Li J, Zhao W and Guo ZV*. A cortico-basal ganglia-thalamo-cortical channel underlying short-term memory. Neuron, 2021. 109, 3486-3499.
- Zhang Z, Yao X, Yin X, Ding J, Huang T, Huo Y, Ji R, Peng H and Guo ZV*. Multi-scale light-sheet fluorescence microscopy for fast whole brain imaging. Front neuroanat, 2021. 15: 732464
- Chen H, Huang T, Yang Y, Yao X, Huo Y, Wang Y, Zhao W, Ji R, Yang H and Guo ZV*. Sparse imaging and reconstruction tomography for high-speed high-resolution whole brain imaging. Cell reports methods, 2021. 1(6), 100089.
- Lu J, Gong X, Yao X, Guang Y, Yang H, Ji R, He Y, Zhou W, Wang H, Wang W, Bai S, Guo H, Guo ZV* and Xie P*. Prolonged chronic social defeat stress promotes less resilience and higher uniformity in depression-like behaviors in adult male mice. Biochemical and Biophysical Research Communications. 2021. 553:107-13
- Huo Y, Chen H and Guo ZV*. Mapping functional connectivity from the dorsal cortex to the thalamus. Neuron, 2020. 107, 1080-1094.
- Guo ZV, Inagaki HK, Daie K, Druckmann S, Gerfen CR and Svoboda K. Maintenance of persistent activity in a frontal thalamocortical loop. Nature. 2017. 545, 181-186.
- Guo ZV, Hires SA, Li N, O'Connor DH, Komiyama T, Ophir E, Huber D, Bonardi C, Morandell K, Gutnisky D, Peron S, Xu N, Cox J, Svoboda K. Procedures for behavioral experiments in head-fixed mice. Plos one. 2014, 9(2): e88678.
- Guo ZV, Li N, Huber D, Ophir E, Gutnisky D, Ting JT, Feng G and Svoboda K. Flow of cortical activity underlying a tactile decision in mice. Neuron. 2014, 81, 179-194.
- Guo ZV, Hart AC and Ramanathan S. Optical interrogation of neural circuits in Caenorhabditis elegans. Nature Methods. 2009, 6, 891-896.
- Guo ZV and Mahadevan L. Limbless undulatory propulsion on land. PNAS. 2008, 105(9), 3179-3184.