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PI, IDG/McGovern Institute, Tsinghua University
Professor, School of Life Sciences, Tsinghua University Office Phone: 010-62772273
Email: zhongyi@biomed.tsinghua.edu.cn |
[Research Focus]
We study neural mechanism of learning and memory using genetics, electrophysiology, behavior and imaging. We firstly reveal the molecular mechanism of active forgetting and will further explore related researches. We also study human memory-related diseases, such as Alzheimer‘s disease, Autism, and Schizophrenia, and make efforts to develop potential drugs.
[Education & Experience]
2015-present PI, IDG/McGovern Institute, Tsinghua University
2015-present Proffessor, School of Life Sciences, Tsinghua University
2015-present PI, Tsinghua-Peking Joint Center for Life Sciences
2004-2015 Professor, Cold Spring Harbor Lab. Cold Spring Harbor1998-2004 Associate Professor, Cold Spring Harbor Lab. Cold Spring Harbor
1995-1998 Senior Staff Investigator, Cold Spring Harbor Lab. Cold Spring Harbor
1992-1995 Staff Investigator, Cold Spring Harbor Lab. Cold Spring Harbor
1985-1991 PhD., Department of Biology, University of Iowa, Iowa City, IA
1982-1984 M.S., Department of Biotechnology and Biological Science, Tsinghua University, Beijing, China.
1978-1982 B.S., Department of Nuclear Engineering, Tsinghua University, Beijing, China.
[Selected Publications]
- Xuchen Zhang, Qian Li, Lianzhang Wang, Zhong-Jian Liu, Yi Zhong*.Active Protection: Learning-Activated Raf/MAPK Activity Protects Labile Memory from Rac1-Independent Forgetting. Neuron. DOI:10.1016/j.neuron.2018.02.025
- Davis, R. L., and Zhong, Y*. (2017). The Biology of Forgetting-A Perspective. Neuron 95, 490-503.
- Zhang, X., Li, Q., Wang, L., Liu, Z. J., and Zhong, Y*. (2016). Cdc42-Dependent Forgetting Regulates Repetition Effect in Prolonging Memory Retention. Cell Rep 16, 817-825.
- Lu, B., Zhao, Y., Zhao, J., Yao, X., Shuai, Y., Ma, W., and Zhong, Y*. (2016). The carboxypeptidase D homolog silver regulates memory formation via insulin pathway in Drosophila. Protein Cell 7, 606-610.
- Liu, Y., Du, S., Lv, L., Lei, B., Shi, W., Tang, Y., Wang, L., and Zhong, Y*. (2016). Hippocampal Activation of Rac1 Regulates the Forgetting of Object Recognition Memory. Curr Biol 26, 2351-2357.
- Li, Q., Zhang, X., Hu, W., Liang, X., Zhang, F., Wang, L., Liu, Z. J., and Zhong, Y*. (2016). Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila. Proc Natl Acad Sci U S A 113, 3072-3077.
- Dong, T., He, J., Wang, S., Wang, L., Cheng, Y., and Zhong, Y*. (2016). Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes. Proc Natl Acad Sci U S A 113, 7644-7649.
- Shuai, Y., Hirokawa, A., Ai, Y., Zhang, M., Li, W., and Zhong, Y.* (2015). Dissecting neural pathways for forgetting in Drosophila olfactory aversive memory. Proc Natl Acad Sci U S A 112, E6663-6672.
- Lu, B., Shao, L., Feng, S., Wang, T., and Zhong, Y*. (2014). The beta-alanyl-monoamine synthase ebony is regulated by schizophrenia susceptibility gene dysbindin in Drosophila. Sci China Life Sci 57, 46-51.
- Zhao, J., Lu, Y., Zhao, X., Yao, X., Shuai, Y., Huang, C., Wang, L., Jeong, S. H., and Zhong, Y*. (2013). Dissociation of rugose-dependent short-term memory component from memory consolidation in Drosophila. Genes Brain Behav 12, 626-632.
- Xie, Z., Huang, C., Ci, B., Wang, L., and Zhong, Y*. (2013). Requirement of the combination of mushroom body gamma lobe and alpha/beta lobes for the retrieval of both aversive and appetitive early memories in Drosophila. Learn Mem 20, 474-481.
- Wang, L., Liang, B., and Zhong, Y*. (2013). Reduced EGFR level potentially mediates the Abeta42-induced neuronal loss in transgenic fruit fly and mouse. Protein Cell 4, 647-649.
- Shuai Y, Hu Y, Qin H, Campbell RA, Zhong Y*. (2011) Distinct molecular underpinnings of Drosophila olfactory trace conditioning. Proc Natl Acad Sci U S A 108: 20201-20206.
- Shao L, Shuai Y, Wang J, Feng S, Lu B, Li Z, Zhao Y, Wang L, Zhong Y*.(2011) Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila. Proc Natl Acad Sci U S A 108: 18831-18836.
- Shuai Y, Zhang Y, Gao L, Zhong Y*. (2011) Stress resistance conferred by neuronal expression of Dominant-Negative Rac in adult Drosophila melanogaster. J. Neurogenetics 25(1-2): 35-39.
- Shuai Y, Lu B, Hu Y, Wang L, Sun K, Zhong Y*. (2010) Forgetting is regulated through Rac activity in Drosophila. Cell 140:579-89.
- Chiang HC, Wang L, Xie Z, Yau A, Zhong Y*. (2010) PI3 kinase signaling is involved in Aβ-induced memory loss in Drosophila. Proc Natl Acad Sci U S A 107:7060-7065.
- Pagani MR, Oishi K, Gelb BD, Zhong Y*. (2009) The phosphatase SHP2 regulates the spacing effect for long-term memory induction. Cell 139:186-98.
- Song Q, Sun K, Shuai Y, Lin R, You W, Wang L, Zhong Y*. (2009) Suppressor of hairless is required for long-term memory formation in Drosophila. J. Neurogenetics 23: 405-411.
- Liu X, Yuan X, Sun K, Shuai Y, Song Q, Wang L, Shao L, Zhao X, Lv Y, Lv Y, Wang L, Zhong Y*. (2008) Genomic screen for expression pattern in adult Drosophila brains in vivo by enhancer trap method and establishment of expression database. Prog Biochem Biophysics 35: 645-649.
- Lu Y, Lu YS, Shuai Y, Feng C, Tully T, Xie Z, Zhong Y*, Zhou HM*. (2007) The AKAP Yu is required for olfactory long-term memory formation in Drosophila. Proc Natl Acad Sci U S A 104(34):13792-7.
- Qian M, Pan G, Sun L, Feng C, Xie Z, Tully T, Zhong Y*. (2007) Receptor-like tyrosine phosphatase PTP10D is required for long-term memory in Drosophila. J Neurosci 27:4396-402.
- Ge X, Hannan F, Xie Z, Feng C, Tully T, Zhou H, Xie Z, Zhong Y*.(2004) Notch signaling in Drosophila long-term memory formation. Proc Natl Acad Sci U S A 101:10172-6.