Time：11:00-12:00，July 17， 2018

Venue：B416, Medical Sciences Building，Tsinghua University

讲座嘉宾：Dr. Mohamed Trebak, Department of Cellular and Molecular Physiology & Cancer Institute

Host：Dr. Bailong Xiao

Topic：Ca2+ signaling in non-excitable cells

Abstract：ORAI (ORAI1, ORAI2, and ORAI3) proteins form a family of highly Ca2+-selective channels at the plasma membrane. ORAIs are activated by stromal-interacting molecules (STIM1 and STIM2), which are Ca2+ sensing proteins located in the endoplasmic reticulum. STIM and ORAI proteins are ubiquitously expressed in all mammalian tissues and form store-operated Ca2+ entry (SOCE) channels. Mutations or altered expression of STIM and ORAI proteins are associated to a number of diseases, including cardiovascular and airway diseases and cancer. Here we will give a historical perspective on this Ca2+ signaling pathway and discuss our current understanding of ORAI channel signaling and regulation and their contribution to several pathologies.