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Shi, Songhai

Date：2018-11-08

Director, IDG/McGovern Institute for Brain Research at Tsinghua University

Dean, School of Life Sciences, Tsinghua University

TsienTang ChairProfessor, Tsinghua University           

Email: shisonghai@mail.tsinghua.edu.cn
                     
        

[Research Focus]                          

Development of the neocortex in the brain is considered to be the crowning achievement of evolution and likely holds the key to the superior mental prowess of humans. The ability of the neocortex to command all higher-order brain functions, such as sensory perception, language, conscious thought and reasoning, depends on the intricate circuitry comprised of a vast number of diverse neurons. Our research focuses on identifying the common commodities of neocortical circuits at both the structural and functional levels, and linking them with animal behaviors, with the ultimate goal of arriving at a circuit- and system-level understanding of neocortical operation and function under normal and disease conditions.

 

[Education & Experience]                         

2021-present       Dean, School of Life Sciences, Tsinghua University
2019-present       School of Life Sciences,Professor & IDG/McGovern Institute for Brain Research at Tsinghua University,Director
2019-present       Weill Cornell Medical College & Memorial Sloan Kettering Cancer Center, USA／Adjunct Professor & Member
2015-2019           Weill Cornell Medical College, USA／Professor
2015-2019           Memorial Sloan Kettering Cancer Center, USA／Member
2011-2015           Weill Cornell Medical College, USA／Associate Professor
2011-2015           Memorial Sloan Kettering Cancer Center, USA／Associate Member／Member
2006-2011           Weill Cornell Medical College, USA／Assistant Professor
2006-2011           Memorial Sloan Kettering Cancer Center, USA／Assistant Member
2001-2006           University of California at San Francisco & Howard Hughes Medical Institute, USA／Postdoctoral Fellow
1996-2001           Cold Spring Harbor Laboratory & State University of New York at Stony Brook, USA／Ph.D.
1991-1996           Tsinghua University, China／B.S.

 

[Selected Publications]                            

  • Yang, J., Dong, Y., Liu, J., Peng, Y., Wang, D., Li, L., Hu, X., Li, J., Wang, L., Chu, J., Ma, J., Shi, H., and Shi, S.-H. (2025) Primary ciliary protein kinase A activity in the prefrontal cortex modulates stress in mice. Neuron 113(8):1276-1289. (PMID: 40056898)
  • Shen, Z.*, Yang, J.*, Zhang, Q.*, Wang, K.*, Hu, X., Ma, J., and Shi, S.-H. (2023) How variable progenitor clones construct a largely invariant neocortex. National Science Review 11(1):nwad247 (PMID: 38274004)
  • Lv, X.*, Li, S.*, Li, J., Yu, X.-Y., Ge, X., Li, B., Hu, S., Lin, Y., Zhang, S., Yang, J., Zhang, X., Yan, J., Joyner, A. L., Shi, H., Wu, Q., and Shi, S.-H. (2022) Patterned cPCDH expression regulates the fine organization of the neocortex. Nature 612(7940):503-511. (PMID: 36477535)
  • Dong, X., Zhang, Q., Yu, X., Wang, D., Ma, J., Ma, J. and Shi, S.-H. (2022) Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex. Nat. Neurosci. 25(7): 865-875. (PMID: 35726058)
  • Shen, Z.*, Lin, Y.*, Yang, J., Jorg, D.J., Peng, Y., Zhang, X., Xu, Y., Hernandez, L., Ma, J., Simons, B.D., and Shi, S.-H. (2021) Distinct Progenitor Behavior Underlying Neocortical Gliogenesis Related to Tumorigenesis. Cell Rep. 34(11) (2021): 108853. (PMID: 33730566)
  • Shao, W.*, Yang, J.*, He, M., Yu, X.-Y., Lee, C.H., Yang, Z., Joyner, A.L., Anderson, K. V., Zhang, J., Tsou, M.B., Shi, H., and Shi, S.-H. (2020) Centrosome Anchoring Regulates Progenitor Properties and Cortical Formation. (* Co-first author) Nature 580:106-112. (PMCID: PMC7138347)
  • Ren, S.Q., Li, Z., Lin, S., Bergami, M., and Shi, S.-H. (2019) Precise Long-range Microcircuit-to-microcircuit Communication Connects the Frontal and Sensory Cortices in the Mammalian Brain. Neuron 104: 1-17. (PMCID: PMC6813886)