（To follow the rules of epidemic prevention in Tsinghua University, please scan the code to sign up for the meeting.）

Time: 14:00-15:30 on Tue., Nov. 24, 2020

Venue: E109, Biomedicine Hall

Host: Dr. Songhai Shi

Topic：Wiring the Brain by Clustered Protocadherin Neural Codes

Abstract: 

There are more than a thousand trillion specific synaptic connections in the human brain and over a million new specific connections are formed every second during the early years of life. The assembly of these staggeringly complex neuronal circuits requires specific cell-surface molecular tags to endow each neuron with a unique identity code to discriminate self from non-self. The clustered protocadherin (Pcdh) genes, which encode a tremendous diversity of cell-surface assemblies, are candidates for neuronal identity tags. In this seminar, I will report our genetic dissection of functions of the clustered Pcdh genes by DNA-fragment editing methods. I will specifically focus on the emerging CTCF 3D architectural mechanisms that generate an enormous number of diverse cell-surface Pcdhs as neural codes in the brain.

报告人简介:

吴强，上海交大系统生物医学研究院和癌基因及相关基因国家重点实验室研究员，博士生导师。系统生物医学教育部重点实验室常务副主任，科技部重大科学研究计划（973）项目首席科学家，享受国务院政府特殊津贴，上海市优秀学术带头人。中国细胞学会表观遗传分会、中国生化分子生物学会基因分会和中国遗传学会基因编辑分会专业委员，中美生命科学家学会终身会员。曾经在复旦大学、纽约州立大学石溪分校和冷泉港实验室学习，哈佛大学、犹他大学和中科院生物物理所工作；曾获得上海市自然科学一等奖和教育部自然科学一等奖（均为第一完成人），上海交通大学教书育人奖，The Second Annual RNA Award, Damon Runyon Research Fellowship Award, American Cancer Society Research Scholar Award, Basil O’Connor Scholar Award等奖项。在分子遗传学和发育生物学相关三维基因组和基因编辑交叉领域取得一系列研究成果，相关论文发表于Cell, Science, Molecular Cell, PNAS, Genome Biology, Protein&Cell, Cell Research, Cell Discovery, eLife, Nature Genetics等学术杂志。

疫情期间因入校需要审批，欢迎校外观众在线参加！

会议 ID：830 904 693

题目:题目题目:柔性和多模态神经界面柔性和多模态神经界面

:柔性和多模态神经界面