| Time | 12:00-13:00, Nov 11, 2022 |
| Venue | E203, Biomedicine Hall, Tsinghua University |
| Host | |
| Speaker | Yinghan Wang (王颖菡) |
| Topic | Investigating the pathogenesis of a bipolar disorder gene in mice |
| Abstract | The pathogenesis of bipolar disorder (BD) has remained enigmatic, largely because genetic animal models based on identified susceptible genes have often failed to show core symptoms of spontaneous mood cycling. However, pedigree and induced pluripotent stem cell (iPSC)-based analyses have implicated that dysfunction in some key signaling cascades might be crucial for the disease pathogenesis in a subpopulation of BD patients. We hypothesized that the behavioral abnormalities of patients and the comorbid metabolic abnormalities might share some identical molecular mechanism. Hence, we investigated the behavioral phenotype of mice with a BD pathogenic gene silenced and identified it as a candidate risk factor for behavioral abnormalities. |
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