Time: 14:00-15:30 on Tue.,May.16, 2023

Venue：E109, Biomedicine Hall

Speaker: Dr.Xin Jin

Host: Dr.Kexin Yuan

Title:  Basal ganglia and action sequencing

Abstract：

The organization of action into sequences underlies many complex behaviors that are essential for organism’s survival and reproduction. Despite of extensive studies on innate action sequences in relation to central pattern generators, how learned action sequences are controlled and organized into proper order and timing remains largely unknown. By combining behavioral analyses, in vivo electrophysiology, genetic and optogenetic tools in mice, here I will present two recent studies from my lab demonstrating how specific neuronal populations in the cortico-basal ganglia circuitry control the order and timing of actions, respectively. These findings have important implications for a wide range of neurological diseases impaired in action sequencing, including Parkinson’s disease and obsessive-compulsive disorder.

Biography：

华东师范大学运动控制与疾病研究中心教授、主任，脑功能基因组学教育部重点实验室研究员。实验室主要采用分子，电生理，光学成像和行为学手段研究大脑基底节神经环路与运动控制，及其在运动和精神疾病中的机理。过去十多年在Nature, Cell, Nature Neuroscience和Neuron等国际顶级学术期刊上发表一系列系统性工作，获得包括葡萄牙神经学会最佳论文奖，美国国立卫生研究院贝内迪克特·拉特利奖，美国神经科学会格鲁伯国际研究奖，埃里森基金会脑老化奖，和麦克奈特记忆和认知障碍奖等国际奖项。