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PI, IDG/McGovern Institute for Brain, Tsinghua University
Professor, School of Life Sciences, Tsinghua University
Lab address：Room A416，Bio-Medical Building, Tsinghua University Email: li-dong@tsinghua.edu.cn |
[Research Focus]
Dong Li’s group focuses on developing novel optical imaging methods, which enable us to measure and study the biological processes with unprecedented precision, such as structures and dynamics of molecular assemblies in living biological systems, interactions between molecules, and behavior of individual molecules, etc. We are greatly enjoying working at the interface of several disciplines, where light, biology and chemistry catalyze each other.
[Education & Experience]
2024.7-present PI, IDG/McGovern Institute for Brain Research, Tsinghua University
2024.7-present Professor, School of Life Sciences, Tsinghua University
2015.12-2024.7 Principal Investigator, Institute of Biophysics, Chinese Academy of Sciences
2006.8-2011.11 Ph.D. in Electronic & Computer Engineering, The Hong Kong University of Science and Technology
2002.9-2006.7 B.Eng. in Optoelectronic Information Engineering, Zhejiang University
2002.9-2006.7 B.Eng. in Optoelectronic Information Engineering, Zhejiang University
[Selected publications]
- Qiao C, Liu S, Wang Y, Xu W, Geng X, Jiang T, Zhang J, Meng Q, Qiao H, Li D*, Dai QH*. A neural network for long-term super-resolution imaging of live cells with reliable confidence quantification. Nat Biotechnol. 2025 Jan 29.
- Qiao C, Chen H, Wang R, Jiang T, Wang Y, Li D*. Deep learning-based optical aberration estimation enables offline digital adaptive optics and super-resolution imaging. Photonics Research, 2024 Dec (3), 474-484
- Qiao C, Li D, Liu Y, Zhang S, Liu K, Liu C, Guo Y, Jiang T, Fang C, Li N, Zeng Y, He K, Zhu X, Lippincott-Schwartz J*, Dai Q*, Li D*. Rationalized deep learning super-resolution microscopy for sustained live imaging of rapid subcellular processes. Nat Biotechnol. 2023 Mar;41(3):367-377.
- Qiao C#, Li D#, Guo Y#, Liu C#, Jiang T, Dai Q*, Li D*. Evaluation and development of deep neural networks for image super-resolution in optical microscopy. Nat Methods. 2021 Feb;18(2):194-202.
- Wang X#*, Liu C#, Zhang S#, Yan H, Zhang L, Jiang A, Liu Y, Feng Y, Li D, Guo Y, Hu X, Lin Y, Bu P, Li D*. N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles. Dev Cell. 2021 Feb 15; 56(5):702-715.
- Gong B#, Guo Y#, Ding S, Liu X, Meng A, Li D*, Jia S*, A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission. Nat Cell Biol. 2021 Jul; 23(7):782-795.
- Xu G#, Liu C#, Zhou S#, Li Q, Feng Y, Sun P, Feng H, Gao Y, Zhu J, Luo X, Zhan Q, Liu S, Zhu S, Deng H*, Li D*, Gao P*. Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion. Mol Cell. 2021 Jul 1;81(13):2823-2837.
- Qin J, Guo Y, Xue B, Shi P, Chen Y, Su Q, Hao H, Zhao S, Wu C, Yu L, Li D*, Sun Y*. ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation. Nat Commun. 2020 Sep 8;11(1):4471.
- Li D#, Zhao Y#, Li D, Zhao H, Huang J, Miao G, Feng D, Liu P, Li D*, Zhang H*. The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation. Cell Rep. 2019 Apr 9;27(2):343-358.
- Guo Y#, Li D#, Zhang S, Yang Y, Liu J, Wang X, Liu C, Milkie D, Moore R, Tulu U, Kiehart D, Hu J, Lippincott-Schwartz J*, Betzig E*, Li D*.Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales. Cell. 2018 Nov 15;175(5):1430-1442.
- Li D, Shao L, Chen BC, Zhang X, Zhang M, Moses B, Milkie DE, Beach JR, Hammer JA, Pasham M, Kirchhausen T, Baird MA, Davidson MW, Xu P, Betzig E*. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics. Science. 2015 Aug 28;349(6251): aab3500.