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Assistant Professor, School of Life Science, Tsinghua University
PI, IDG/McGovern Institute for Brain, Tsinghua University
PI, Center for Life Science
Office: B202, Biomedicine Hall, Tsinghua University, Beijing,10084 |
[Research Focus]
The cerebral cortex is the seat of higher-order brain functions. It consists of a multitude of specialized, precisely positioned and interconnected cell types that assemble into specialized neuronal circuits. One major goal of neuroscience is to understand how small pools of neural progenitor cells generate the vast diversity of neuronal cell types during brain development. Our research group seeks to uncover cellular and molecular mechanisms regulating the emergence of neuronal diversity in the developing cerebral cortex. We also study the role of cellular heterogeneity in neurodevelopmental disorders (NDDs), with the ultimate goal of identifying cell types and their maturation stages that are closely associated with NDDs and understanding cell type-specific functions of disease susceptibility genes in cortical development.
2015-2020 Postdoctoral Fellow, King's College London
2013-2015 Postdoctoral Fellow, University of Edinburgh
2008-2013 Ph.D., University of Edinburgh
2005-2008 M.Sc., Nankai University
- Ma S, Skarica M, Li Q, Xu C, Risgaard RD, Tebbenkamp ATN, Mato-Blanco X, Kovner R, Krsnik Ž, de Martin X, Luria V, Martí-Pérez X, Liang D, Karger A, Schmidt DK, Gomez-Sanchez Z, Qi C, Gobeske KT, Pochareddy S, Debnath A, Hottman CJ, Spurrier J, Teo L, Boghdadi AG, Homman-Ludiye J, Ely JJ, Daadi EW, Mi D, Daadi M, Marín O, Hof PR, Rasin MR, Bourne J, Sherwood CC, Santpere G, Girgenti MJ, Strittmatter SM, Sousa AMM*, Sestan N*. (2022) Molecular and cellular evolution of the primate dorsolateral prefrontal cortex. Science. abo7257.
- Shi Y#, Wang M#, Mi D#, Lu T, Wang B, Dong H, Zhong S, Chen Y, Sun L, Zhou X, Ma Q, Liu Z, Wang W, Zhang J, Wu Q*, Marín O*, Wang X*. (2021) Mouse and human share conserved transcriptional programs for interneuron development. Science. 10; 374.
- Mi, D#., Li, Z#., Lim, L., Li, M., Moissidis, M., Yang, Y., Gao, T., Hu, T.X., Pratt, T., Price, D.J., Sestan, N., and Marín, O*. (2018) Early emergence of cortical interneuron diversity in the mouse embryo. Science. 360, 81-85.
- Lim, L#., Mi, D#., Llorca, A., and Marín, O*. (2018) Development and Functional Diversification of Cortical Interneurons. Neuron. 100, 294-313.
- Mi D, Manuel MN, Huang Y-T, Mason JO and Price DJ*. (2018) Pax6 lengthens G1 phase and decreases oscillating Cdk6 levels in murine embryonic cortical progenitors. Front. Cell. Neurosci. 12:419. doi: 10.3389/fncel.2018.00419.
- Manuel MN#, Mi D#, Mason JO and Price DJ*. (2015) Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor. Front. Cell. Neurosci. 9:70. doi: 10.3389/fncel.2015.00070.
- Mi, D., Carr, C.B., Georgala, P.A., Huang, Y.T., Manuel, M.N., Jeanes, E., Niisato, E., Sansom, S.N., Livesey, F.J., Theil, T., Hasenpusch-Theil, K., Simpson, T., Mason, J., and Price D.J*. (2013) Pax6 Exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and Hypophosphorylation of pRb. Neuron. 78, 269–284.