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PI, IDG/McGovern Institute for Brain Research, Tsinghua University
PI, Tsinghua-Beijing Universities Center for Life Sciences
Assistant Professor, School of Medicine, Tsinghua University Email: zhoumu@mail.tsinghua.edu.cn
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[Research Focus]
The ultimate goal of our lab is to understand the neural mechanisms of animal behaviors in physiological and pathological conditions. To achieve this goal, we choose to focus on the circuit mechanisms controlling motor functions, which are easy to be quantified and interpreted. Specifically, we are interested in the cerebellar and brainstem neural circuits controlling fine motor movements. Using techniques including circuit tracing, circuit manipulations, in vivo recordings and customized behavior paradigms, we aim to characterize circuit mechanisms underlying normal motor functions and essential tremor, the most common movement disorder.
[Education & Experience]
2021-present Assistant Professor, School of Medicine,Tsinghua University
2021-present PI, IDG/McGovern Institute for Brain Research at Tsinghua University
2021-present PI, Tsinghua-Beijing Universities Center for Life Sciences
2014-2020 Postdoctoral Fellow, Stanford University, USA
2008-2014 Ph.D., University of Southern California, USA
2003-2007 B.S., University of Science and Technology of China
[Selected Publications]
1. Zhou M #, Melin MD, Xu W, Südhof TC. (2020) Dysfunction of parvalbumin neurons in the cerebellar nuclei produces action tremor in mice. Journal of Clinical Investigation 10, 5142-5156. (# Corresponding author)
2. Zhou M #, Liu Z, Melin MD, Ng YH, Xu W, Südhof TC #. (2018) A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory. Nature Neuroscience 11, 1515-1519 (# Co-corresponding authors)
3. Zhou M *, Liang F *, Xiong XR, Li L, Li H, Xiao Z, Tao HW, Zhang LI. (2014) Scaling down of balanced excitation and inhibition by active behavioral states in auditory cortex. Nature Neuroscience 6, 841-850 (* Equal contribution)
4. Zhou M, Li YT, Yuan W, Tao HW, Zhang LI. (2014) Synaptic mechanisms for generating temporal diversity of auditory representation in the dorsal cochlear nucleus. Journal of Neurophysiology 5, 1358-1368
5. Zhou M, Tao HW, Zhang LI. (2012) Generation of intensity selectivity by differential synaptic tuning: fast-saturating excitation but slow-saturating inhibition. Journal of Neuroscience 50, 18068-18078