Development of advanced fluorescent probes for structural and functional imaging of biological systems


(To follow the rules of epidemic prevention in Tsinghua University, please scan the code to sign up for the meeting.  Welcome to the online lecture, Tencent Conference  ID: 642 358 324)

Time: 14:00-15:30 on Tue., June. 15, 2021

Venue: E109, Biomedicine Hall

Speaker: Dr. Kiryl D. Piatkevich

Host: Dr. Yinqing Li

Title:Development of advanced fluorescent probes for structural and functional imaging of biological systems


Our brain mediates everything that we think, feel, sense, and do. The brain is an incredibly complex organ - while the brain computes events on a millisecond scale, it spans years of a lifetime and at the same time, while the brain is organized at the nanoscale level, it spans meters in size. Therefore, holistic understanding of the brain, from intracellular processes to cell-cell interactions across the whole organ, requires scalable integrated technologies that can simultaneously map neuronal computations on both functional and structural levels within the intact brain in vivo. In the talk, Kiryl Piatkevich will present the development and validation of novel scalable molecular and imaging technologies that enable recording neural activity with ultrahigh temporal resolution and mapping the nanoscale cellular structures on the same subset of neurons within intact brain circuits. Kiryl Piatkevich will also present my recent efforts on applying these technologies to reveal new insight into how the brain works. In the final part of the talk, Kiryl Piatkevich will provide perspectives on the development of advanced molecular technologies to study the brain.


Kiryl Piatkevich received an M.S. degree in Chemistry at Lomonosov Moscow State University. Then he enrolled in a joint Ph.D. program between Albert Einstein College of Medicine in New York and Lomonosov Moscow State University to work on the development of fluorescent proteins for multicolor intravital two-photon imaging under the supervision of Vladislav Verkhusha and Sergei Varfolomeev. After completing his graduate work, Kiryl Piatkevich joined the Synthetic Neurobiology group led by Ed Boyden at MIT. His postdoctoral work was focused on engineering new scalable molecular and imaging technologies for mapping brain computations. Starting 2019, Dr. Piatkevich leads the Molecular BioEngineering Group ( in the School of Life Science at Westlake University, which develops cutting-edge optical technologies for analyzing, controlling, and repairing complex biological systems such as the brain. His group also applies developed technologies systematically to reveal the underpinning molecular mechanism of brain disorder as well as understand ground truth principles of neural codes. The long-term goal of the group is the development of advanced brain-machine interfaces by means of light.