Wu, Jian

      Professor,Chief physician,Department of Neurology, Beijing Tsinghua Changgung Hospital
      PI,IDG/McGovern Institute for Brain Research at Tsinghua University

[Research Interests]   

Our research group has long been committed to the basic and clinical research of ischemic and hypoxic nerve injury diseases. By using the research methods of cell biology, molecular biology, immunology, genetics, ethology and neuro-imaging, our research group focuses on the signal transduction, material exchange, injury and repair between nerve tissue and cerebrovascular tissue.Using stem cell derivatives combined with biomaterials and other tissue engineering to provide new treatment methods for ischemic and hypoxic nerve injury, and exploring the application of new materials and AI technology in the scientific research and clinical work of nervous system diseases, so as to lay the foundation for new diagnosis and treatment methods and precision medicine.

[Education & Experience]                             

2021-present    IDG/McGovern Institute for Brain Research at Tsinghua University /Professor

2015-present    Department of Neurology, Beijing Tsinghua Changgung Hospital, Tsinghua University/Professor,Chief physician

2007-2015        Department of Neurology, Xuanwu Hospital Capital Medical /Professor,Chief physician

2009-2012        Department of Neurology, Capital Medical University  /PhD

2003-2007        University of Tennessee,USA/Assistant Professor

2003-2006        University of Memphis,USA/ MHA

2000-2003        The Jackson Lab, USA/Postdoctoral Fellow

1995-2012        Department  of  Neurology, Capital Medical University  Master&PhD

1986-1991        Department of Clinical Medicine, Tongji Medical University/Bachelor

[Selected Publicaitions]                             

  • Yan Zhao ,... Jian Wu* and Xianghua Fang*.Prevalence and Risk Factors Comparison of Anterior and Posterior Intracranial Arterial Stenosis.Evidence-Based Complementary and Alternative Medicine.Volume 2022, Article ID 7710374, 8 pages.
  • Gao C, Jia W, ... Wu, J*. Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke[J]. Journal of neuroinflammation, 2021, 18(1): 1-16.
  • Song, X., Wei, Q., Zhao, X., Hou, D., Zhao, H., Wang, L., ...  Wu, J*. (2021). Association between Short-Term Blood Pressure Variability and Intracranial Atherosclerotic Plaque Vulnerability: A High-Resolution Magnetic Resonance Imaging Study. Journal of atherosclerosis and thrombosis, 63164.
  • Song X, ...  Wu, J*..  Association between blood pressure and intracranial artery stenosis in a Chinese population[J]. The Journal of Clinical Hypertension, 2020
  • Song X , Zhao X , Liebeskind D S, ...  Wu, J*. Associations between systemic blood pressure parameters and intraplaque hemorrhage in symptomatic intracranial atherosclerosis: a high-resolution MRI-based study[J]. Hypertension Research, 2020, 43(7)
  • Xu W , Gao C , ...Wu J. CD151 Alleviates Early Blood–Brain Barrier Dysfunction After Experimental Focal Brain Ischemia in Rats[J]. Cellular and Molecular Neurobiology, 2020:1-12.
  • Song X , Zhao X , Liebeskind D S, ...  Wu, J*. Incremental value of plaque enhancement in predicting stroke recurrence in symptomatic intracranial atherosclerosis[J]. Neuroradiology, 2020.
  • Song X, Xue S, Wu J*. Isolated symptomatic middle cerebral artery stenosis in young adults: clinical prognosis and vascular change[J]. Int J Neurosci, 2017,127(7):573-578.
  • Song X, Xue S, Zhao J, , ...  Wu, J*. Screening for Fabry's disease in young patients with ischemic stroke in a Chinese population[J]. Int J Neurosci, 2017,127(4):350-355.