A Multi-model System to Study Molecular Neurodegeneration



Time: 9:00-10:00 on Tues.,June.28, 2022

Zoom Link:850 9219 8969


Speaker: Dr. Ke Zhang

Host: Dr.Song-Hai Shi

Title:  A Multi-model System to Study Molecular Neurodegeneration



Neurodegenerative diseases are a group of age-related, fatal, and currently incurable and unpreventable diseases. A major challenge in therapeutic development for these diseases is an incomplete understanding of the pathogenic mechanism. We use a combination of model systems, including Drosophila, neurons derived from patient-induced pluripotent stem cells, and human cell lines, to dissect the molecular mechanisms underlying pathogenesis. Particularly, we focus on how stress granules, RNA/protein granules assembled when cells are under stress, contribute to disease pathogenesis and whether they can be therapeutic targets. In addition, we also use human multi-omic analyses to identify novel targets.