Wu, Jiamin


     PI, IDG/McGovern Institute for Brain Research, Tsinghua University

     Assistant Professor,Department of Automation, Tsinghua University

    Office Phone: +86-10-62773621





[Research Focus]

Multiscale observation from subcellular structures to organs may lead to great breakthroughs in life science. However, it has long been restricted by the space-bandwidth product, optical aberrations, phototoxicity, and so on. I have been focusing on the great challenge of intravital mesoscale imaging and devoted myself to the interdisciplinary study of computational imaging and multiscale understanding of complicated biological phenomena. I have proposed a series of new microscopic imaging framework including camera-array-based gigapixel mesoscale microscopy, and scanning light field microscopy to overcome the barriers of intravital imaging, with orders of magnitude improvement in spatiotemporal resolution, imaging data throughput, and orders of magnitude reduction in phototoxicity for long-term observations. My study opens up a new horizon for the study of large-scale intercellular interactions in mammals. However, there remains great data challenges for analyzing and modeling the multiscale behaviors of the living systems spanning organelles, cells, tissue, and organs. Therefore, my future work plans to develop better intravital mesoscale imaging instruments and data analysis platforms for diverse applications in neuroscience, oncology, and immunology, especially for the neural coding mechanism on the basis of millions of neurons.


[Education & Experience]                           

2021-present    Assistant Professor at Department of Automation, Tsinghua University
2022-present    PI at IDG/McGovern Institute for Brain Research, Tsinghua University
2019-2021        Postdoc. at Department of Automation, Tsinghua University
2014-2019        Ph.D. Control Science and Engineering, Tsinghua University,
2016-2018        Visiting Graduate Student,    Massachusetts General Hospital, Harvard Medical School,
2010-2014        B.Eng.    Department of Automation, Tsinghua University 


[Selected Publications]                            

  • Jiamin Wu#, Yuduo Guo#, Chao Deng#, Anke Zhang, Hui Qiao, Zhi Lu, Jiachen Xie, Lu Fang*, and Qionghai Dai*; An integrated imaging sensor for aberration-corrected 3D photography, Nature, 2022.
  • Jiamin Wu#; Zhi Lu#; Dong Jiang#; Yuduo Guo; Hui Qiao; Yi Zhang; Tianyi Zhu; Yeyi Cai; Xu Zhang; Karl Zhanghao; Hao Xie; Tao Yan; Guoxun Zhang; Xiaoxu Li; Zheng Jiang; Xing Lin; Lu Fang; Bing Zhou; Peng Xi; Jingtao Fan*; Li Yu*; Qionghai Dai*; Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale. Cell, 2021, 184(12): 3318-3332.
  • Yi Zhang#; Zhi Lu#; Jiamin Wu#,*; Xing Lin; Dong Jiang; Yeyi Cai; Jiachen Xie; Yuling Wang; Tianyi Zhu; Xiangyang Ji*; Qionghai Dai*; Computational optical sectioning with an incoherent multiscale scattering model for light-field microscopy, Nature Communications, 2021, 12: 6391.
  • Tao Yan#; Jiamin Wu#; Tiankuang Zhou#; Hao Xie; Feng Xu; Jingtao Fan; Lu Fang; Xing Lin*; Qionghai Dai*; Fourier-space Diffractive Deep Neural Network, Physical Review Letters, 2019, 123(2): 023901.
  • Jingtao Fan#; Jinli Suo#; Jiamin Wu#; Hao Xie#; Yibing Shen; Feng Chen; Guijin Wang; Liangcai Cao; Guofan Jin; Quansheng He; Tianfu Li; Guoming Luan; Lingjie Kong*; Zhenrong Zheng*; Qionghai Dai*; Video-rate imaging of biological dynamics at centimetre scale and micrometre resolution, Nature Photonics, 2019, 13(11): 809-816.