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副教授，清华大学基础医学院
研究员，清华-IDG/麦戈文脑科学研究院
研究员，清华-北大生命联合中心
办公电话: +86-10-62792669
电子邮件: zengcai.guo@biomed.tsinghua.edu.cn 办公地址：北京市海淀区清华大学生物医学馆B104
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[研究兴趣]
学习和记忆的神经机制。人类大脑包含上百个不同的脑区，这些脑区通过纷繁复杂的神经纤维连接，构成能根据不同情况实时灵活处理信息的脑网络。外界的感觉信息进入大脑后以工作记忆的形式短暂存储，以指导下一步的行动。工作记忆是学习、推理、决策、意识等认知活动的基础。本实验室以小鼠为主要模式系统，结合光遗传学操控、多通道电生理、双光子成像和定量行为学研究多脑区的神经网络如何促进工作记忆信息的产生，如何维持工作记忆；多脑区神经动力学如何协同变化以支持工作记忆行为的学习；同时开发新型结构和功能成像方法促进多脑区神经动力学的研究。通过脑网络功能研究，结合新型技术手段，最终理解工作记忆脑网络的运行机制，为工作记忆疾病的治疗提供新的思路，并启发新型人工智能计算模型。
[简历]
| 2024-至今 | 副教授，清华大学基础医学院 |
| 2020-2024 | 副教授，清华大学医学院 |
| 2015-2020 | 助理教授，清华大学医学院 |
| 2015-至今 | 研究员，清华-IDG/麦戈文脑科学研究院 |
| 2015-至今 | 研究员，清华-北大生命联合中心 |
| 2010-2015 | 博士后，美国霍华德休斯研究所詹宁斯校区 |
| 2004-2010 | 博士，应用数学，哈佛大学 |
| 2002-2004 | 硕士，固体力学，清华大学 |
| 1998-2002 | 学士，工程力学，清华大学 |
[部分发表]
- Zhou S, Zhu Q, Eom M, Fang S, Subach OM, Ran C, ... Guo ZV*, Subach FV* and Piatkevic KD*. A sensitive soma-localized red fluorescent calcium indicator for in vivo imaging of neuronal populations at single-cell resolution. PLoS biology, 2025, 23(4): e3003048.
- Zhang Y, Wang M, Zhu Q, Guo Y, Liu B, Li J, Yao X, Kong C, Zhang Y, Huang Y, Qi H, Wu J*, Guo ZV* & Dai H*. Long-term mesoscale observation of native 3D intercellular dynamics across a mammalian organ by RUSH3D. Cell, 2024.
- Ocklenburg S* and Guo ZV*. Cross-hemispheric communication: Insights on lateralized brain functions. Neuron, 2024, 10.1016/j.neuron.2024.02.010
- Jaramillo J*, and Guo ZV*. Thalamocortical Contributions to Neural Dynamics and Behavior. Book Chap of the Cerebral Cortex and thalamus, Edited by Martin Usrey and S. Murray Sherman
- Geng J, Tang Y, Yu Z, Gao Y, Li W, Lu Y, Wang B, Zhou H, Li P, Liu N, Wang P, Fan Y, Yang Y*, Guo ZV* and Liu X*. Chronic Ca2+ imaging of cortical neurons with long-term expression of GCaMP-X. eLife, https://doi.org/10.7554/eLife.76691
- Yin X, Wang W, Li J, and Guo ZV*. Lateralization of short-term memory in the frontal cortex. Cell Reports, 2022. 40, 111190.
- Lu J, Zhang Z, Yin X, Tang Y, Ji R, Chen H, Guang Y, Gong X, He Y, Zhou W, Wang H, Cheng K, Wang Y, Chen X, Xie P*, and Guo ZV*. An entorhinal-visual cortical circuit regulates depression-like behaviors. Molecular Psychiatry, 2022. 27, 3807–3820.
- Tang Y, Yang H, Chen X, Zhang Z, Yao X, Yin X and Guo ZV*. Opposing regulation of short-term memory by basal ganglia direct and indirect pathways that are coactive during behavior. BioRxiv, 2021: 2021.12. 15.472735.
- Wang Y, Yin X, Zhang Z, Li J, Zhao W and Guo ZV*. A cortico-basal ganglia-thalamo-cortical channel underlying short-term memory. Neuron, 2021. 109, 3486-3499.
- Zhang Z, Yao X, Yin X, Ding J, Huang T, Huo Y, Ji R, Peng H and Guo ZV*. Multi-scale light-sheet fluorescence microscopy for fast whole brain imaging. Front neuroanat, 2021. 15: 732464
- Chen H, Huang T, Yang Y, Yao X, Huo Y, Wang Y, Zhao W, Ji R, Yang H and Guo ZV*. Sparse imaging and reconstruction tomography for high-speed high-resolution whole brain imaging. Cell reports methods, 2021. 1(6), 100089.
- Lu J, Gong X, Yao X, Guang Y, Yang H, Ji R, He Y, Zhou W, Wang H, Wang W, Bai S, Guo H, Guo ZV* and Xie P*. Prolonged chronic social defeat stress promotes less resilience and higher uniformity in depression-like behaviors in adult male mice. Biochemical and Biophysical Research Communications. 2021. 553:107-13
- Huo Y, Chen H and Guo ZV*. Mapping functional connectivity from the dorsal cortex to the thalamus. Neuron, 2020. 107, 1080-1094.
- Guo ZV, Inagaki HK, Daie K, Druckmann S, Gerfen CR and Svoboda K. Maintenance of persistent activity in a frontal thalamocortical loop. Nature. 2017. 545, 181-186.
- Guo ZV, Hires SA, Li N, O'Connor DH, Komiyama T, Ophir E, Huber D, Bonardi C, Morandell K, Gutnisky D, Peron S, Xu N, Cox J, Svoboda K. Procedures for behavioral experiments in head-fixed mice. Plos one. 2014, 9(2): e88678.
- Guo ZV, Li N, Huber D, Ophir E, Gutnisky D, Ting JT, Feng G and Svoboda K. Flow of cortical activity underlying a tactile decision in mice. Neuron. 2014, 81, 179-194.
- Guo ZV, Hart AC and Ramanathan S. Optical interrogation of neural circuits in Caenorhabditis elegans. Nature Methods. 2009, 6, 891-896.
- Guo ZV and Mahadevan L. Limbless undulatory propulsion on land. PNAS. 2008, 105(9), 3179-3184.