 |
研究员，清华-IDG/麦戈文脑科学研究院
教授，清华大学药学院
教授，清华-北大生命联合中心
办公电话：86-10-6277 3981
实验室电话：86-10-6277 3952 电子邮件: xbailong@biomed.tsinghua.edu.cn |
[研究兴趣]
离子通道是控制细胞兴奋性和其它功能的一类重要跨膜蛋白。遗传突变或生理调节性紊乱所导致的离子通道功能失调可以致使包括神经疾病、心血管病、免疫疾病及代谢疾病等在内的很多重大疾病（统称为离子通道病）。因而，对于离子通道的结构和功能的研究不仅有助于我们了解这一类重要蛋白，并有助于相关新药或新疗法的设计开发。
我们实验室综合利用分子生物学、生物化学、结构生物学、生物物理学、神经生物学、钙成像技术、电生理、基因敲除小鼠的建立和行为学测试、高通量靶点或药物筛选等研究手段，着重开展温度门控型以及机械力门控型离子通道（例如机械力门控Piezo离子通道）的鉴定发现、结构功能关系以及生理学和病理学意义的研究。这类被称之为感受性的离子通道可以作为包括温度、化学物质及其机械力等触觉刺激的受体从而对控制我们五感之一的触觉的发生和调控以及其它机械力传感生理过程具有极其重要的作用。通过对这些离子通道的研究，我们期望能对触觉和痛觉的分子生物学机制以及机械力传感在其它生理过程中的作用能有更好的了解，并期望最终能开发出以这些通道为靶点的新型药物。
实验室目前的主要研究方向包括：
1）机械门控Piezo离子通道结构功能、生理／病理学意义、药物筛选；
2）STIM1/Orai离子通道温度敏感性的生理学意义；
2）STIM1/Orai离子通道温度敏感性的生理学意义；
3）签定发现新型机械门控或温度门控离子通道或受体。
[简历]
2021–至今 清华大学药学院教授，清华-北大生命联合中心教授
2021-至今 清华-IDG/麦戈文脑科学研究院教授
2021-至今 清华-IDG/麦戈文脑科学研究院教授
2013–2021 清华大学药学院研究员，清华-北大生命联合中心研究员
2013–2021 清华-IDG/麦戈文脑科学研究院研究员
2007–2012 美国Scripps研究院博士后
2007–2012 美国诺华研究基金会的基因组研究所访问学者
2001–2006 加拿大卡尔加里大学心血管和呼吸系统科学博士
2013–2021 清华-IDG/麦戈文脑科学研究院研究员
2007–2012 美国Scripps研究院博士后
2007–2012 美国诺华研究基金会的基因组研究所访问学者
2001–2006 加拿大卡尔加里大学心血管和呼吸系统科学博士
1997–2001 中山大学生物化学学士
[部分发表]
- Jingyi Yuan*, Li Wang*, Sijia Liu*, Jie Geng, Xudong Chen, Xuzhong Yang, Xiaochun Zhang, Boxue Tian, Xueming Li# , Bailong Xiao# (2026) Structural conservation and ion selectivity adaptation of the mechanically activated PIEZO channel. Neuron March30, 2026
- Xiao Zhu*, Jiajie Zhu*, Wenhao Liu, Yaxiong Cui, Cheng Bi, Bailong Xiao# (2026) Piezo1-mediated mechanotransduction in choroid plexus epithelial cells governs ciliogenesis and cerebrospinal fluid homeostasis. Neuron March 30, 2026
- Wenhao Liu*, Xiaochun Zhang, Qijing He, Yang Meng, Boxue Tian, Bailong Xiao# (2025) Spring-like mechanics enable rapid inactivation and stochastic single-channel gating of the mechanically activated PIEZO channel. Cell Rep 2025 Dec23;44(12):116615.doi: 10.1016/j.celrep.2025.116615. Epub 2025 Nov 26.
- Jinghui Jiang*, Wei Guo*, Xudong Chen, Qijing He, Yubo Wang, Xiaohui Zhu, Liying Yan, Jie Qiao# , Bailong Xiao# (2025) The fetal hydrops-associated single-residue mutation L322P disrupts mechanical but not chemical activation of the PIEZO1 ion channel. Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e2503793122. doi:10.1073/pnas.2503793122. Epub 2025 Aug 11. PMID: 40789030
- Sijia Liu*, Xuzhong Yang*, Xudong Chen*, Xiaochun Zhang*, Jinghui Jiang*, Jingyi Yuan, Wenhao Liu, Li Wang, Heng Zhou, Kun Wu, Boxue Tian# , Xueming Li# ,Bailong Xiao# (2025) An intermediate open structure reveals the gating transition of the mechanically activated PIEZO1 channel. Neuron. 2025 Feb 19;113(4):590-604.e6. doi: 10.1016/j.neuron.2024.11.020. Epub 2024 Dec 23. PMID: 39719701
- Tingxin Zhang, Cheng Bi, Yiran Li, Lingyun Zhao, Yaxiong Cui, Kunfu Ouyang# ,Bailong Xiao# (2024) Phosphorylation of Piezo1 at a single residue, serine-1612, regulates its mechanosensitivity and in vivo mechanotransduction function. Neuron 2024 Sep 10:S0896-6273(24)00581-6. doi: 10.1016/j.neuron.2024.08.009.
- Bailong Xiao# (2024) Mechanisms of mechanotransduction and physiological roles of PIEZO channels. Nature Reviews Molecular and Cell Biology 2024Nov;25(11):886-903. doi: 10.1038/s41580-024-00773-5. Epub 2024 Sep 9.
- Celeste M. Nelson, Bailong Xiao, Sara A. Wickström, Yves F. Dufrêne, Daniel J.Cosgrove, Carl-Philipp Heisenberg, Sirio Dupont, Amy E. Shyer, Alan R. Rodrigues, Xavier Trepat, Alba Diz-Muñoz (2024) Mechanobiology: Shaping the future of cellular form and function. Cell, VOICES| VOLUME 187, ISSUE 11, P2652-2656, MAY 23, 2024. DOI:https://doi.org/10.1016/j.cell.2024.04.006
- Shaopeng Chi* Yaxiong Cui* , Haiping Wang* , Jinghui Jiang, Tingxin Zhang, Suhua Sun, Zhuan Zhou, Yi Zhong, Bailong Xiao# (2022) Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions.Neuron. 2022 Sep 21;110(18):2984-2999.e8. doi: 10.1016/j.neuron.2022.07.010. Epub 2022 Aug 12.
- Xuzhong Yang* , Chao Lin* , Xudong Chen* , Shouqin Li* ,Xueming Li# , Bailong Xiao# (2022) Deformation and curvature-gating of the PIEZO1 channel in lipid membranes. Nature 2022 Apr;604(7905):377-383. doi: 10.1038/s41586-022-04574-8. Epub 2022 Apr 6.
- Jing Wang*, Jinghui Jiang*, Xuzhong Yang, Li Wang, Bailong Xiao# (2022) Tethering Piezo channels to the actin cytoskeleton for mechanogating via the E-cadherin-β- catenin mechanotransduction complex. Cell Rep. 2022 Feb 8;38(6):110342. doi: 10.1016/j.celrep.2022.110342.
- Wei-Zheng Zeng# and Bailong Xiao# (2021) Eukaryotic Mechanosensitive Ion Channels (book chapter). Nonclassical Ion Channels in the Nervous System，Edited by Xu Tian-le, Long-Jun Wu, ISBN 9780367623951, Published August 20, 2021 by CRC Press.
- Yao Rong*, Jinghui Jiang*, Yiwei Gao*, Jianli Guo, Danfeng Song, Wenhao Liu, Mingmin Zhang, Yan Zhao# , Bailong Xiao# , Zhenfeng Liu# (2021) TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells. Elife. 2021 Aug 19;10:e71474. doi:10.7554/eLife.71474.
- Yang Jiang*, Xuzhong Yang*, Jinghui Jiang*, Bailong Xiao# (2021) Structural Designs and Mechanogating of the Mechanosensitive Piezo channels. Trends Biochem Sci. 2021 Feb 17:S0968-0004(21)00022-0. doi: 10.1016/j.tibs.2021.01.008.
- Fan Jiang, Kunlun Yin, Kun Wu, Mingmin Zhang, Shiqiang Wang, Heping Cheng, Zhou Zhou, Bailong Xiao# (2021) The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction. Nature Commun. 2021 Feb 8;12(1):869. doi: 10.1038/s41467-021-21178-4.
- Jie Geng*, Wenhao Liu*, Heng Zhou*, Tingxin Zhang*, Li Wang*, Mingmin Zhang, Yiran Li, Bo Shen, Xueming Li# , Bailong Xiao# (2020) A plug-and-latch mechanism for gating the mechanosensitive Piezo channel. Neuron. 2020 May 6;106(3):438- 451.e6.doi: 10.1016/j.neuron.2020.02.010 (Featured by Neuron Previews).
- Bailong Xiao# (2020) Levering mechanically activated Piezo channels for potential pharmacological intervention. Annual Review of Pharmacology and Toxicology 2020 Jan 6;60:195-218. doi: 10.1146/annurev-pharmtox-010919-023703.
- Li Wang* , Heng Zhou* , Mingmin Zhang* , Wenhao Liu* , Tuan Deng, Qiancheng Zhao, Yiran Li, Jianlin Lei, Xueming Li# , Bailong Xiao# (2019) Structure and mechanogating of the mammalian tactile channel PIEZO2. Nature (Article) 2019 Sep;573(7773):225-229. doi: 10.1038/s41586-019-1505-8. Epub 2019 Aug 21. (Featured by Nature News & Views).
- Weijia Sun* , Shaopeng Chi* , Yuheng Li, Shukuan Ling, Yingjun Tan, Youjia Xu, Fan Jiang, Jianwei Li, Caizhi Liu, Guohui Zhong, Dengchao Cao, Xiaoyan Jin, Dingsheng Zhao, Xingcheng Gao, Zizhong Liu, Bailong Xiao# , and Yingxian Li# (2019) Themechanosensitive Piezo1 channel is required for bone formation. Elife. 2019 Jul 10;8. pii: e47454. doi: 10.7554/eLife.47454.
- Mingmin Zhang, Yanfeng Wang, Jie Geng, Shuqin Zhou, Bailong Xiao# (2019) Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice. Cell Rep. 2019 Feb 5;26(6):1419-1431.e4. doi: 10.1016/j.celrep.2019.01.056.
- Xiaoling Liu*, Haiping Wang*, Yan Jiang*, Qin Zheng*, Matt Petrus, Mingmin Zhang, Sisi Zheng, Christian Schmedt, Xinzhong Dong, Bailong Xiao# (2019) STIM1 thermosensitivity defines the optimal preference temperature for warm sensation in mice. Cell Res. 2019 Jan 3. doi: 10.1038/s41422-018-0129-0.
- Qiancheng Zhao*, Heng Zhou*, Xueming Li# , Bailong Xiao# (2018) The mechanosensitive Piezo1 channel: a three-bladed propeller-like structure and a lever- like mechanogating mechanism. FEBS J. 2019 Jul;286(13):2461-2470. doi: 10.1111/febs.14711. Epub 2018 Dec 14.
- Qiancheng Zhao*, Heng Zhou*, Shaopeng Chi*, Yanfeng Wang*, Jianhua Wang, Jie Geng, Kun Wu, Wenhao Liu, Tingxin Zhang, Meng-Qiu Dong, Jiawei Wang, Xueming Li# , Bailong Xiao (2018) Structure and Mechanogating Mechanism of the Piezo1 Channel. Nature (Article) 2018 Feb 22;554(7693):487-492. doi: 10.1038/nature25743. Epub 2018 Jan 22. (Featured by Nature News & Views; Selected by Faculty of 1000.) (Highly cited paper and this study has been cited by the textbook of Principals of Neurobiology edited by Dr. Liqun Luo)
- Yanfeng Wang*, Shaopeng Chi*, Huifang Guo, Guang Li, Li Wang, Qiancheng Zhao, Yu Rao, Liansuo Zu, Wei He, Bailong Xiao# (2018) A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat Commun. 2018 Apr 3;9(1):1300. doi: 10.1038/s41467-018-03570-9.
- Yubo Wang, Bailong Xiao# (2018). The mechanosensitive Piezo1 channel: structural features and molecular bases underlying its ion permeation and mechanotransduction. J Physiol. 2018 Mar 15;596(6):969-978.
- Tingxin Zhang*, Shaopeng Chi*, Fan Jiang, Qiancheng Zhao, Bailong Xiao (2017). A protein interaction mechanism for suppressing the mechanosensitive Piezo channels. Nat Commun. 2017 Nov 27;8(1):1797.
- Jie Geng*, Qiancheng Zhao*, Tingxing Zhang*, Bailong Xiao# (2017). In Touch With the Mechanosensitive Piezo Channels: Structure, Ion Permeation and Mechanotransduction. Curr Top Membr. 2017;79:159-195
- Qiancheng Zhao*, Kun Wu*, Jie Geng*, Shaopeng Chi*, Yanfeng Wang, Peng Zhi, Mingmin Zhang, Bailong Xiao# (2016). Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels. Neuron. 2016 Mar 16;89(6):1248-63. (Previewed by Neuron; Reported by www.Eurekalert.org
- Jingpeng Ge*, Wanqiu Li*, Qiancheng Zhao*, Ningning Li*, Maofei Chen, Peng Zhi, Ruochong Li, Ning Gao# , Bailong Xiao# , Maojun Yang# (2015). Architecture of the mammalian mechanosensitive Piezo1 channel. Nature (Article). Nov 5;527(7576):64- 9. (Highly cited paper).
- Bertrand Coste* (co-first), Bailong Xiao* (co-first), Jose S. Santos, Ruhma Syeda, Jorg Grandl, Kathryn S. Spencer, Sung Eun Kim, Manuela Schmidt, Jayanti Mathur, Adrienne E. Dubin, Mauricio Montal, Ardem Patapoutian (2012). Piezo Proteins Are Pore-forming Subunits of Mechanically Activated Channels. Nature. 2012 Feb 19;483(7388):176-81 PMID:22343900 (Highly cited paper and this study has been cited by the textbook of Principals of Neurobiology edited by Dr. Liqun Luo; Selected by Faculty of 1000; Featured by Nature News & Views; TSRI News & Views; Reported by Science Daily)