时间：2017年12月19日 13:30-14:30?

地点：医学科学楼B323

讲座嘉宾：郑宁教授

• 美国华盛顿大学医学院药理系教授

• 霍华德·休斯医学研究所研究员

  

主持人:

肖百龙教授, 清华-IDG/麦戈文脑科学研究院研究员

题目:

Deciphering Voltage-gated Sodium and Calcium Channels through Prokaryotic Ancestors.

摘要:

Voltage-gated sodium channels (NaVs) and calcium channels (CaVs) are involved in electrical signaling, contraction, secretion, synaptic transmission, and other physiological processes activated in response to membrane depolarization. Despite their physiological importance, the structural mechanisms underlying the functions of these closely related proteins have remained elusive. Bacterial NaVs have structures analogous to a single domain of eukaryotic NaVs and CaVs and are their likely evolutionary ancestor. In this talk, I will review recent work that has led to new understanding of NaVs and CaVs through functional and high-resolution structural studies of their prokaryotic ancestors. Despite being separated during evolution by more than two billion years, our studies of the bacterial channels have provided new insights into the voltage-dependent activation, ion conductance, ion selectivity, and drug block of their human counterparts.