研究员 清华-IDG/麦戈文脑科学研究院 助理教授 清华大学临床医学院 副主任医师 清华大学附属北京清华长庚医院神经外科               电子邮件：wzhang007@tsinghua.edu.cn

[研究兴趣]   

弥漫中线胶质细胞瘤（Diffuse Midline Glioma, DMG）是严重危害人类健康的中枢神经系统（Central Nervous System, CNS）恶性肿瘤。该肿瘤细胞沿CNS的中线部位（常见丘脑、脑干、脊髓），呈弥漫性、侵袭性生长，手术无法彻底切除，特异性辅助治疗方式尚缺。我们运用多组学、表观遗传学、分子生物学、免疫学等方法探索：

（1）基于不同原发部位DMG恶性演进机理；

（2）基于表观遗传治疗的免疫疗法；

（3）DMG液体活检技术及分子影像学诊断方法；

（4）DMG早筛、肿瘤进展与预后标记物研发；

[简历]                             

[部分发表]                             

• Jing LK, Qian ZH, Gao Q, Sun R, Zhen ZL, Wang GH, Yang XY, Li HT, Guo TN, Zhang W*. Diffuse Midline Glioma Treated with Epigenetic Agent Based Immunotherapy. Accepted. Signal Transduct Target Ther. 2023;8(1):23.
• Chen WJ, Zhang X, Han H, Lv JN, Kang EM, Zhang YL, Liu WP, He XS, Wang J, Wang GH, Yu YB, Zhang W*. The different role of YKL-40 in glioblastoma is a function of MGMT promoter methylation status. Cell Death Dis. 2020; 11(8): 668-681.
• Zhang X, Zhang W^#, Mao XG, Cao WD, Zhen HN, Hu SJ. Malignant Intracranial High Grade Glioma and Current Treatment Strategy. Curr Cancer Drug Targets. 2019; 19(2): 101-108. 
• Zhang W, Fulci G, Wakimoto H, Cheema AT, Buhrman JS, Jeyaretna DS, Stemmer-Rachamimov AO, Rabkin SD, Martuza RL. Combination of Oncolytic Herpes Simplex Viruses Armed with Angiostatin and IL-12 Enhances Antitumor Efficacy in Human Glioblastoma Models. Neoplasia. 2013; 15(6):591-9.
• Zhang W, Fulci G, Buhrman JS, Stemmer-Rachamimov AO, Chen JW, Wojtkiewicz GR, Weissleder R, Rabkin SD, Martuza RL. Bevacizumab With Angiostatin-armed oHSV Increases Antiangiogenesis and Decreases Bevacizumab-induced Invasion in U87 Glioma. Mol Ther. 2012; 20(1):37-45.
• Zhang W, Kawanishi M, Miyake K, Kagawa M, Kawai N, Murao K, Nishiyama A, Fei Z, Zhang X, Tamiya T. Association between YKL-40 and adult primary astrocytoma. Cancer. 2010; 116(11):2688-97.
• Zhang W, Murao K, Zhang X, Matsumoto K, Diah S, Okada M, Miyake K, Kawai N, Fei Z, Tamiya T. Resveratrol represses YKL-40 expression in human glioma U87 cells. BMC Cancer. 2010; 10:593.
• Liu BL, Cheng JX, Zhang W^#, Zhang X, Wang R, Lin H, Huo JL, Cheng H. Quantitative detection of multiple gene promoter hypermethylation in tumor tissue, serum, and cerebrospinal fluid predicts prognosis of malignant gliomas. Neuro Oncol. 2010; 12(6):540-8.