[研究兴趣]                          

分子如何形成细胞？细胞又是如何形成组织？本课题组主要关注细胞和发育生物学中的精细结构和动态过程。应用光学/电子显微镜、生物物理技术、遗传学和生物化学方法，我们主要研究细胞和发育过程中细胞骨架复合物的结构、功能和发生。在一些项目中，我们还与理论物理学家合作进行跨尺度建模分析。本课题组的主要模型系统是果蝇感觉神经元，但也包括其他类型的细胞，包括果蝇生殖细胞、培养的哺乳动物细胞和脊椎动物纤毛细胞。通过广泛而深入地研究相关的分子机制，我们希望了解细胞动力学调控的普遍性规律。                               

 [简历]   

[部分发表]                    

• # Sun, L., Cui, L., Liu, Z., Wang, Q., Xue, Z., Wu, M., Sun, T., Mao, D., Ni, J., Pastor-Pareja, J.C., Liang X.* (2021). Katanin p60-like 1 sculpts the cytoskeleton in mechanosensory cilia. Journal of Cell Biology, 220. (Cover featured article & Special collection)
• Diao, L., Liu, M., Song, Y., Zhang, X., Liang, X.*, and Bao, L.* (2021). alpha1A and alpha1C form microtubules to display distinct properties mainly mediated by their C-terminal tails. Journal of Molecular and Cellular Biology 10.1093/jmcb/mjab062
• # Liao, M., Liang, X., and Howard, J.* (2021). The narrowing of dendrite branches across nodes follows a well-defined scaling law. Proc Natl Acad Sci U S A 118.
• Li, S., Wan, K.Y., Chen, W., Tao, H., Liang, X.*, and Pan, J*. (2020). Functional exploration of heterotrimeric kinesin-II in IFT and ciliary length control in Chlamydomonas. eLife 9.
• Song Y., Zhang Y., Pan Y., He J., Wang Y., Chen W., Guo J., Deng H., Xue Y.*, Fang X.*, Liang X.*. The microtubule end-binding affinity of EB1 is enhanced by a dimeric organization that is susceptible to phosphorylation. Journal of Cell Science 2020: jcs.241216.
• # Sun, L., Gao, Y., He, J., Cui, L., Meissner, J., Verbavatz, J.M., Li, B., Feng, X., and Liang, X.* (2019). Ultrastructural organization of NompC in the mechanoreceptive organelle of Drosophila campaniform mechanoreceptors. Proc Natl Acad Sci U S A 116, 7343-7352. Highlighted in Faculty 1000
• Sun, T., Song, Y., Dai, J., Mao, D., Ma, M., Ni, J.Q., Liang, X., and Pastor-Pareja, J.C*. (2019). Spectraplakin Shot Maintains Perinuclear Microtubule Organization in Drosophila Polyploid Cells. Developmental Cell 49, 731-747 e737.
• Liang, X.* (2019). Microtubule nucleation and dynamic instability in interphase fission yeast. Journal of Molecular and Cellular Biology 11, 941-943.
• # Liang, X.*, and Howard, J.* (2018). Structural Biology: Piezo Senses Tension through Curvature. Current Biology 28, R357-R359.
• Feng, S., Song Y., Shen M., Xie S., Li W., Lu Y., Yang Y., Ou G., Zhou J., Wang F., Liu W., Yan X.*, Liang X.* and Zhou T.* (2017). "Microtubule-binding protein FOR20 promotes microtubule depolymerization and cell migration." Cell Discovery 3: 17032.
• # Liang, X.*, and Howard, J. (2017). Structural Biology: A Force-Sensitive Ion Channel Springs to Life. Current Biology 27, R1017-R1020.