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研究员，清华-IDG/麦戈文脑科学研究院
实验室地址：清华大学医学楼E102，邮编100084副教授，清华大学生命科学学院
研究员，清华-北大生命联合中心
国家优秀青年基金获得者
办公电话:+86-10-62790589（实验室）
+86-62796065（办公室）
办公室地址：清华大学医学楼D214，邮编100084电子邮件: weizhang0505@@126.com |
[研究兴趣]
大脑与体内器官的双向交流由复杂的神经和激素系统控制，对维持人体的生理和心理稳态起着至关重要的作用。体内感受不仅广泛参与本能行为的调控，还会影响高级认知行为，例如记忆、情绪和自我意识。我们实验室采用“受体的生物物理学--神经元的细胞生物学—神经环路的功能学—动物行为学”这一自下而上的模式，探讨体内感受的分子与神经环路机制。
[简历]
2017-至今 清华-IDG/麦戈文脑科学研究院、清华大学生命科学学院、清华-北大生命联合中心 研究员
2010-2016 加州大学旧金山分校/霍华德休斯医学院 博士后
2004-2010 中国科学院神经科学研究所 博士
2000-2004 山东大学生命科学学院 学士
[部分发表]
- Liwei Zhang*#, Xuan Guo#, Wei Zhang*. Nutrients and pheromones promote insulin release to inhibit courtship drive. Science Advances. 2022
- Tingting Yang, Zixuan Yuan, Chenxi Liu, Ting Liu, Wei Zhang*. A neural circuit integrates pharyngeal sensation to control feeding. Cell Reports. 2021.
- Rui Luo, Yuxiang Zhang, Yinjun Jia, Yan Zhang, Zongyang Li, Jieqing Zhao, Ting Liu, Wei Zhang*. Molecular basis and homeostatic regulation of Zinc taste. Protein & Cell. 2021.
- Pingping Wang, Yinjun Jia, Ting Liu, Yuh-Nung Jan*, Wei Zhang*. Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor. Neuron. 2020.
- Chenxi Liu, Bei Zhang, Liwei Zhang, Tingting Yang, Zhewei Zhang, Zihua Gao. A neural circuit encoding mating states tunes defensive behavior in Drosophila. Nature Communications. 2020.
- Liwei Zhang#*, Jie Yu#, Xuan Guo, Jianhua Wei, Ting Liu, Wei Zhang*. Parallel mechanosensory pathways direct oviposition decision of Drosophila. Current Biology. 2020.
- Yawen Li #, Yufei Hu#, Jiawei Wang, Xin Liu*, Wei Zhang*; Linfeng Sun*. Structural Insights into a Plant Mechanosensitive Ion Channel MSL1. Cell Reports. 2020.
- Yufei Hu, Zhilin Wang, Ting Liu, Wei Zhang*. Piezo-like Gene Regulates Locomotion in Drosophila Larvae. Cell Reports. 2019.
早期发表：
- Li, J.#, Zhang, W#., Guo, Z., Wu, S., Jan, L.Y., and Jan, Y.N. (2016). A defensive kicking behavior in response to mechanical stimuli mediated by Drosophila wing margin bristles. J. Neurosci. 36:11275-11282. #: Co-first authors.Guo Y.#, Wang Y.#, Zhang, W.#, Meltzer S.#, Zanini, D.#, Yu Y., Li, J., Cheng, T., Guo, Z., Wang Q., Jacobs J. S., Sharma Y., Eberl D., Goepfert, M., Jan, L.Y., Jan, Y.N. and Wang Z. Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion. P.N.A.S. 2016 Jun 28;113(26):7243-8. #: Co-first authors.
- Zhang, W.#, Cheng, L.E.#, Kittelmann, M. #, Li, J., Petkovic, M., Cheng, T., Jin, P., Guo, Z., Goepfert, M., Jan, L.Y., Jan, Y.N. (2015). Ankyrin Repeats Act as a Tether for Conveying Force to Gate the NOMPC Mechanotransduction Channel. Cell. 10 September 2015, 162, Issue 6, p1391–1403. *: Co-first authors.
- Zhang, W#., Yan, Z. #, Li, B., Jan, Y.L., Jan, Y.N. (2014). Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae. eLife. 2014; 10.7554/eLife.03293. #: Co-first authors.
- Zhang, W., Yan, Z., Jan, Y.L., Jan, Y.N. (2013). Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae. P.N.A.S. vol. 110, no. 33.
- Yan, Z. #, Zhang, W. #, He, Y., Gorczyca, D., Xiang, Y., Cheng, L., Meltzer, S., Jan, Y.L., Jan, Y.N. (2013). Drosophila NompC is a mechanotransduction channel subunit for gentle-touch sensation. Nature. 2013 Jan 10; 493(7431): 221-5. #: Co-first authors.
- Hu, A. #, Zhang, W. #, Wang, Z. (2010). Functional feedback from mushroom bodies to antennal lobes in the Drosophila olfactory pathway. P.N.A.S. vol. 107 no. 22 10262-10267. #: Co-first authors.
- Zhang, W., Ge, W., and Wang, Z. (2007). A toolbox for light control of Drosophila behaviors through Channelrhodopsin 2-mediated photoactivation of targeted neurons. Eur. J. Neurosci. 26: 2405-2416.