研究员，清华-IDG/麦戈文脑科学研究院     助理教授，清华大学自动化系 脑与认知科学研究所      地址：清华大学中央主楼307     办公电话：+86-10-62773621     电子邮件：wujiamin@tsinghua.edu.cn

[研究兴趣]   

从亚细胞到器官的时空跨尺度观测有望带来生命科学的重大突破，却长期受制于空间带宽积、光学像差、光毒性等物理局限。瞄准这一国际难题，我致力于计算光学、显微仪器与跨尺度数据理解的交叉研究，提出了曲面光场阵列新架构，建立了空-角-谱耦合采样模型，突破空间带宽积与高维数据传输瓶颈；提出了扫描光场成像新原理，克服了空间与角度精度间的固有矛盾；提出了频域光学神经网络，建立了感算一体光场成像新范式。研制出系列光场智能成像仪器，将活体成像的有效数据通量和时空分辨率均提升2个数量级，光毒性降低3个数量级，为研究哺乳动物大规模细胞间相互作用提供了利器。未来的研究工作，将进一步开发介观尺度活体显微仪器与高通量介观数据处理分析平台，建立从亚细胞、组织到器官的多尺度动力学模型，为揭示神经、肿瘤、免疫新现象和新机理等生命科学重大问题突破提供变革性工具。

[简历]                             

[部分发表]                             

• Jiamin Wu^#, Yuduo Guo^#, Chao Deng^#, Anke Zhang, Hui Qiao, Zhi Lu, Jiachen Xie, Lu Fang*, and Qionghai Dai*; An integrated imaging sensor for aberration-corrected 3D photography, Nature, 2022.
• Jiamin Wu^#; Zhi Lu^#; Dong Jiang^#; Yuduo Guo; Hui Qiao; Yi Zhang; Tianyi Zhu; Yeyi Cai; Xu Zhang; Karl Zhanghao; Hao Xie; Tao Yan; Guoxun Zhang; Xiaoxu Li; Zheng Jiang; Xing Lin; Lu Fang; Bing Zhou; Peng Xi; Jingtao Fan*; Li Yu*; Qionghai Dai*; Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale. Cell, 2021, 184(12): 3318-3332.
• Yi Zhang^#; Zhi Lu^#; Jiamin Wu^#,*; Xing Lin; Dong Jiang; Yeyi Cai; Jiachen Xie; Yuling Wang; Tianyi Zhu; Xiangyang Ji*; Qionghai Dai*; Computational optical sectioning with an incoherent multiscale scattering model for light-field microscopy, Nature Communications, 2021, 12: 6391.
• Tao Yan^#; Jiamin Wu^#; Tiankuang Zhou^#; Hao Xie; Feng Xu; Jingtao Fan; Lu Fang; Xing Lin^*; Qionghai Dai^*; Fourier-space Diffractive Deep Neural Network, Physical Review Letters, 2019, 123(2): 023901.
• Jingtao Fan^#; Jinli Suo^#; Jiamin Wu^#; Hao Xie^#; Yibing Shen; Feng Chen; Guijin Wang; Liangcai Cao; Guofan Jin; Quansheng He; Tianfu Li; Guoming Luan; Lingjie Kong^*; Zhenrong Zheng^*; Qionghai Dai^*; Video-rate imaging of biological dynamics at centimetre scale and micrometre resolution, Nature Photonics, 2019, 13(11): 809-816.