| 时间 |
2023年10月17日，12:00-13:00 |
| 地点 |
生物医学馆E203 |
| 主持人 |
医学院苑克鑫副教授 |
| 报告人 |
陈柔妤（普博三年级） |
| 题目 | Exploring the role of auditory thalamus in arousal |
| 摘要 | General arousal or wakefulness is the basis of most motivated behaviors. On top of general arousal, specific types of arousal can be induced by internal needs or external cues, associated with specific motivational states, and lay a foundation for the expression of specific motivated behaviors, including eating, reward-seeking, evading predators, etc. Here, we discovered that the medial sector of the auditory thalamus (ATm) in mice is a thalamic hub controlling both general and defensive arousal. The spontaneous activity of VGluT2-expressing ATm (ATmVGluT2+) neurons was correlated with and causally contributed to wakefulness. In sleeping mice, sustained ATmVGluT2+ population responses were predictive of sensory-induced arousal, the likelihood of which was markedly decreased by inhibiting ATmVGluT2+ neurons or multiple downstream pathways. In awake mice, ATmVGluT2+ activation led to heightened arousal accompanied by excessive anxiety and avoidance behavior. Notably, blocking their neurotransmission abolished alerting stimuli-induced defensive behaviors. These findings may shed light on the comorbidity of sleep disturbances and abnormal sensory sensitivity in specific brain disorders. |
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