时间: 14:00-15:30 on Tues.,Mar.4, 2025

地点：生物医学馆U6-059

主讲人: Dr.Guoqiang Bi

主持人: Dr. Kexin Yuan

题目: Exploring the nervous system across scales

摘要：

The brain is a complex system spanning multiple spatiotemporal scales, from protein molecules organizing into intricate nano-machines in the synapse to many neurons interconnected via synapses to form circuits across the brain. In the past decade, we have employed and developed various imaging methods to explore this complexity over different scales. At the microscopic scale, we have employed cryo electron tomography (cryoET) and correlative light-electron microscopy (CLEM) to visualize ultrastructural features of synapses in their native state, revealing unique mesophasic organization of neurotransmitter receptors. At the mesoscopic scale, we have developed an ultra-high speed volumetric imaging approach, VISoR, that enables visualization of the whole-brain structure of the rhesus monkey, revealing unexpected trajectories and complex arborization patterns of individual thalamocortical axons. Beyond the brain, we have developed a blockface-VISoR system to achieve high-speed imaging of the whole mouse body at micron-resolution, and to explore previously unattainable features of the peripheral nerve fibers and its interaction with other tissues throughout the entire body.

简介：

毕国强，中国科学技术大学讲席教授、中国科学院深圳先进技术研究院双聘教授。北京大学物理学学士，加州大学伯克利分校生物物理学博士，曾任匹兹堡大学医学院神经生物学助理教授、副教授。主要从事神经生物学与生物物理学研究，发现海马神经元放电时间依赖的突触可塑性（STDP）及其生物物理机制和计算规则，近期工作通过发展与应用冷冻光电关联成像和超高速三维荧光成像等显微成像新技术，以及大数据分析方法解析神经突触和环路的结构与功能。